All data were recorded at a sampling rate of 800 Hz and all EMG data were band-pass filtered between 50 and 350 Hz and full-wave rectified. It was ensured that the EMG electrodes were placed closer to motor points of the ulnar part of the hand. For EMG, two electrodes were used, placed at flexor (EMG1) and extensor (EMG2) muscles, respectively. An accelerometer weighing 2 g was attached to the dorsum of the affected hand in the middle of the third metacarpal bone during the recording. Tremor was recorded for a period of 30 s in this posture where the hand was held against gravity. The other types of tremors also found in MS patients (intention and rest tremor) were not evaluated in this study due to their limited added diagnostic value. The postural tremor was recorded from the more affected side, while subjects extended their hands and fingers in parallel with the resting forearm. During the acquisition, the patients were asked to sit in an armchair with comfortable posture. The data recording conditions were set to be uniform for all three groups. However, none of these measures of ataxia or the clinical assessments have provided consensus in the clinical routine or have enabled us in detangling different tremorgenesis or its underlying neural mechanism. finger-to-nose task, spiral drawing, handwriting and visual tracking or more complex accelerometric and EMG techniques. Several clinical and neurophysiological methods have been employed in the assessment of MS tremor, eg. caused by the disease have been investigated to estimate the scale of ailment. Previously, varying symptoms including measure of acquired ataxia, the degree of disability etc. Discrimination between these tremor types which all have the basis in dysfunction of the cerebellar system is a challenge not only for diagnostic purpose but also for having insight into the mechanisms of disability and neurobiological underpinnings.
The most frequently observed tremor types in MS are cerebellar tremors which overlaps with other tremor types like Essential tremor (ET) and Parkinsonian tremor (PT). Tremor is a common symptom affecting around half of the Multiple Sclerosis (MS) patients.
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